Endocrine Abstracts

Background: In obesity the relationship between white adipose tissue expansion and neovascularisation becomes uncoupled leading to inadequate perfusion of adipose tissue. Under these circumstances the secretory profile of adipocytes becomes metabolically unfavourable and pro-atherosclerotic. Therefore, targeting white adipose tissue may provide a potential therapeutic strategy to combat the negative metabolic and cardiovascular consequences of obesity. Here, we validated a mur...

Type 2 diabetes is preceded by insulin resistance, followed by increased endothelial cell production of superoxide and reduction in bioavailability of the vasoprotective signalling molecule, nitric oxide (NO). We demonstrated in preclinical models that type 2 diabetes also causes resistance to insulin-like growth factor-1 (IGF-1) mediated glucose lowering and endothelial NO release. This study aimed to examine the effect of the endothelial cell-specific combination of insulin ...