Endocrine Abstracts

Differential diagnoses of sellar, parasellar and suprasellar pathologies other than tumors such as common adenoma, rathke cleft cysts and meningioma and craniopharyngiomas were presented. This retrospective study was performed including 25 patients who were operated or treated medically in between 2008 and 2019. The patients were analyzed with preoperative/postoperative magnetic resonance imaging (MRI), endocrinological and neuro-ophthalmologic examination results. Pre and pos...

Autoimmune hypothalamitis has been implicated in idiopathic central diabetes insipidus (DI) due to antibodies against vasopressin producing hypothalamic cells. Lymphocytic infiltration of hypothalamus has been reported in patients with lymphocytic hypophysitis (LH) manifesting as hypopituitarism with DI. These patients can also have other associated autoimmune diseases. Here, we report a case of a male patient who presented with headache, poor orientation, partial hypopituitar...

Women affected by Cushing’s disease (CD) are often infertile due to abnormal follicular development or anovulation. In these patients, first line treatment is pituitary surgery, which is effective in more than 83% of cases with microadenomas, but only in about 35% of those with macroadenomas. When surgery do not normalize circulating ACTH and cortisol concentrations, such drugs, e.g. ketoconazole or metirapone, and radiotherapy are used as adjuvant treatment. Concerning r...

Acromegaly is usually caused by a GH-secreting pituitary adenoma. Although fertility is frequently impaired, pregnancy can be possible due to improvement in diagnosis and treatment modalities. Tumour enlargement and nontumoral lactotroph enlargement related with pregnancy can compress the optic chiasm and cause visual impairment. Optimal management of acromegaly during pregnancy is not well established. In this paper our experience about the clinical, laboratory, radiologic da...

Exposure to supraphysiologic doses of exogenous glucocorticoids is associated with gastrointestinal (GI) complications such as peptic ulcer disease, gastrointestinal hemorrhage, duodenal ulcer, and colonic diverticular perforation (DP). Patients receiving high dose glucocorticoids, for rheumatological or autoimmune disease are at increased risk for lower gastrointestinal tract abscesses and perforation. However, little is known about GI complications in endogenous hypercortiso...

Non-hodgkin lymphoma (NHL) is a hematological tumor caused by abnormal lymphoid proliferation. NHL can arise in any part of the body, including central nervous system (CNS). However, hypothalamus involvement is a rare presentation. Here, we report a case of hypothalamic infiltration of NHL Diffuse Large B-cell lymphoma (DLBCL) in a 21 years old male patient with panhypopituitarism and diabetes insipidus. The patient was admitted to the hospital with a history of nausea, vomiti...