ea0099p432 | Adrenal and Cardiovascular Endocrinology | ECE2024
Xu Mengjie
, Tourigny David S
, Lippert Juliane
, Crastin Ana
, Appenzeller Silke
, Asia Miriam Felicitas
, Podstawka Oskar
, Elhassan Yasir
, Skordilis Kassiani
, Prete Alessandro
, Ronchi Cristina L
Background: Adrenocortical adenomas (ACA) can be associated with different degrees of cortisol excess. Genetic alterations in the cAMP/PKA pathway are observed in up to 60% of cases with overt Cushing syndrome (CS-ACA) and 15% of cases with mild autonomous cortisol secretion (MACS-ACA), while variants in the gene coding for β-catenin (CTNNB1) are more frequent in MACS-ACA and non-functioning adrenal tumours (NFAT). We aimed to test whether somatic variants could ...