ea0029p1819 | Thyroid cancer | ICEECE2012
Sykorova V.
, Vaclavikova E.
, Dvorakova S.
, Halkova T.
, Ryska A.
, Laco J.
, Kodetova D.
, Kodet R.
, Duskova J.
, Astl J.
, Betka J.
, Hoch J.
, Cap J.
, Vlcek P.
, Lukas J.
, Bendlova B.
Introduction: Activating point mutations in the RAS genes (H-RAS, K-RAS, N-RAS) are reported in thyroid tumors. The aim of this study was to determine the frequency of RAS mutations in 98 patients with thyroid tumors.Methods: DNA was extracted from 72 fresh frozen thyroid samples and 26 paraffin-embedded formalin-fixed samples. The cohort contained 83 PTCs (56 FVPTCs, 14 mixed follicular-classical types, 11 classical variants and two other rare variants)...