ea0077p139 | Adrenal and Cardiovascular | SFEBES2021
Russell Georgina
, Upton Thomas
, Zavala Eder
, Methlie Paal
, Simunkova Katerina
, Berinder Katerina
, Botusan Ileena
, Vassiliadi Dimitria
, Tsagarakis Stelios
, Kampe Olle
, Husebye Eystein
, Lightman Stafford
, Oksnes Marianne
, Bensing Sophie
Patients on long term glucocorticoid replacement therapy have higher rates of morbidity and mortality. One causative factor may be non-physiological cortisol replacement. We have developed as part of the ULTRADIAN consortium (https://www.uib.no/en/ultradian) the U-RHYTHM, an ambulatory bio-sampling device that can collect clinical samples using in-vivo microdialysis every 20 minutes over the 24hour day whilst individuals continue with their normal everyday activities....