ea0086p266 | Reproductive Endocrinology | SFEBES2022
Fernandes-Freitas Isabel
, Milona Alexandra
, Ramos-Pittol Jose
, Manchishi Stephen
, Rainbow Kara
, Lam Brian
, Tadross John
, Beucher Anthony
, Colledge William
, Cebola Ines
, Murphy Kevin
, Miguel-Aliaga Irene
, Yeo Giles
, Dhillo Waljit
, Owen Bryn
Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It is thought to require estrogen to have simultaneous positive and negative feedback effects on two spatially-distinct regions of the hypothalamus, the arcuate nucleus and AVPV nucleus. However, the mechanistic basis for this differential effect is not known. Therefore, we mapped the genomic binding of the estrogen receptor alpha (ERα) in bot...