Endocrine Abstracts

Introduction: PCOS women appear to have an adverse body composition (BC). The aim of this study was to compare BC in lean PCOS in comparison to controls and to assess possible metabolic consequences.Methods: We evaluated 150 lean PCOS women (BMI: 20.96±2.06 kg/m2; age: 25.50±4.52 years) diagnosed using ESHRE/ASRM criteria, and 39 lean BMI-matched healthy women (BMI: 20.33±2.16 kg/m2; age: 27.67±5.39 years). BC wa...

Introduction: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a dimeric enzyme that catalyzes the reduction of cortisone to cortisol within the endoplasmic reticulum. Loss of this activity results in a disorder termed cortisone reductase deficiency type 1 (CRD). Only mutations in H6PD gene, which encodes an enzyme supplying cofactor for the reaction, have been identified as the cause of disease. Biochemical features of CRD are increased cortisol clearance and A...