Endocrine Abstracts

Background: Thyroid autoimmunity is the most prevalent autoimmune disorder among women of reproductive age and has been linked to pregnancy loss. In recurrent pregnancy loss (RPL), couples suffer several consecutive losses resulting in physical as well as psychological strains. Thyroid autoimmunity has been suggested as a risk factor in RPL, but most studies have focused on thyroid peroxidase antibodies (TPOAbs), not taking into account the presence of thyroglobulin antibodies...

Objective: Thyroid peroxidase antibody (TPOAb) positivity is the most important risk factor for overt/subclinical hypothyroidism and partly guides levothyroxine treatment indications during pregnancy. TPOAb positivity is usually defined by manufacturer cutoffs which are typically derived in non-pregnant populations with concentrations ≥95th percentile. Besides the general lack of assay uniformity, current TPOAb positivity cutoffs are likely to underestimate gestational t...

Introduction: Thyroid autoimmunity has been associated with pregnancy loss. A possible mechanism is an overactive maternal immune system leading to rejection of the fetal allograft. In women with recurrent pregnancy losses (RPL), we investigated the association of thyroid peroxidase antibodies (TPOAbs) with number of losses and outcome of first pregnancy after referral.Methods: Prospective study of women with RPL (≥3) followed at the RPL Unit, Cope...

Introduction: Autoimmune thyroid disease is associated with other autoimmune diseases. However, most studies are register-based cohort studies or investigate selected patient populations. In a large national cross-sectional population-based study, we investigated positivity of thyroid peroxidase- or thyroglobulin-antibodies (TPOAbs or TgAbs) in association with non-thyroidal autoimmune disease.Methods: As part of The Danish Investigation of Iodine Intake...

Background: Pregnancy loss affects approximately 25% of pregnancies, of which 40% have no detectable chromosome abnormalities and are suspected to be caused by maternal comorbidity. Pregnancy loss has been associated with specific endocrine disorders, e.g. autoimmune thyroid disease (AITD), polycystic ovarian syndrome (PCOS) or diabetes mellitus (DM). Because of the well-described overlap between these endocrine disorders, we hypothesized that pregnancy loss is associated with...