ea0049ep179 | Endocrine tumours and neoplasia | ECE2017
Lamy Constance
, Hadoux Julien
, Mercier Lionel
, Bailleux Dorian
, Hescot Segolene
, Paci Angelo
, Baudin Eric
, Broutin Sophie
Introduction: Malignant paraganglioma/pheochromocytoma (MPP) are very rare neuroendocrine tumors with heterogeneous prognostic and no gold-standard treatment. MPP can be associated with germline mutations at SDH-x genes which encode for the succinate dehydrogenase that catalyzes the oxidation of succinate to fumarate. SDH-x mutations lead to inactivation of the enzyme and thus accumulation of succinate.Aim: This project aims to evaluate...