ea0011p809 | Thyroid | ECE2006
Palos F
, Perez O
, Alvarez-Iglesias V
, Cameselle J
, Barreiro F
, Araujo D
, Argueso R
, Botana M
, Cabezas JM
, Dominguez L
, Martinez T
, Nuño J
, Rueda JC
, Lado-Abeal J
Toxic adenomas (TA) and toxic multinodular goiters (TMNG) are frequent causes of hyperthyroidism in Galicia, an endemic goiter area. In some European countries, 4080% of toxic goiters are caused by TSH receptor (TSHr) and Gs alfa-subunit (Gsa) mutations that activate cAMP pathway.Aims: To study 1) the prevalence of TSHr and Gsa mutations in TMNG and TA from Galicia, 2) the clonality of sequenced samples, 3) the constitutive activity of the identifi...