Endocrine Abstracts

Hair loss after surgical treatment for acromegaly has been rarely described. We report a case of a patient with acromegaly that presented with hair loss after surgical treatment.We describe a case of a 73-year female that was diagnosed with acromegaly. Transesphenoidal surgery was performed with complete tumour resection and no immediate complications. Postoperative IGF -1, GH and OGTT for GH were measured at 12 weeks confirming biochemical remission. Th...

Introduction: The widespread use of highly-active antiretroviral therapy (HAART) has drastically improved the life expectancy of patients with human immunodeficiency virus (HIV) infection. However, many of these drugs show multiple interactions with other treatments; protease inhibitors (PI) are especially troublesome as they interact with the hepatic cytochrome P450. There have been previous reports of both Cushing’s syndrome and adrenal insufficiency in patients treated...

Introduction: Patients with primary adrenal insufficiency (PAI) require lifelong corticoids replacement and they are at risk of therapy-related osteoporosis and cardiovascular complications.Objectives: Determine the prevalence of cardiovascular risk factors, osteoporosis, and other toxicities related with corticoids treatment.Material and methods: Retrospective, descriptive study in patients with PAI follow up in our service during...

Introduction: Transsphenoidal surgery (TS) is used for pituitary and suprasellar tumors. It has a risk of damaging the pituitary axis and developing hypocortisolism, a potential life threating risk.Objetive: Incidence of hypocortisolism after TS, postsurgery cortisol (PSC) levels that predict hypocortisolism and potential risk factors for hypocortisolism after TS.Methods: Prospective study in patients who underwent TS in 2016. Gluc...

Introduction: Patients referred for adrenal incidentalomas (AI) are increasing. Current guidelines are controversial on diagnosis and length of follow-up.Objectives: Analyze clinical, radiologic and hormonal characteristics of patients with AI. Evaluate the number and usefulness of tests needed for diagnosis, clinical outcome and follow up.Material and methods: Observational, retrospective study in patients with AI in our endocrino...

Introduction: Endonasal endoscopic transsphenoidal surgery (EETS) for a sellar or suprasellar mass poses potential complications, including transient or permanent hypopituitarism. Adrenocortical insufficiency is especially worrisome given its potentially life-threatening course, if untreated. Usual clinical practice includes administration of perioperative “stress doses” of steroids followed by long term steroid replacement until the hypothalamic-pituitary-adrenal ax...

Introduction: Clinically non-functioning pituitary adenomas (NFPA) are heterogeneous group. Some previous research has found that this type of pituitary adenomas may be smaller and have better prognostic in men. The aim of this study is to analyze if there are gender-related differences in NFPA.Material and methods: Retrospective study of patients with NFPA followed up in regional hospitals (Community of Madrid, Spain). All NFPA had molecular analysis. T...

Aim: Evaluate the predictive value of the Pituitary Apoplexy Score (PAS) for predicting hormonal and visual recovery after surgery or conservative management of patients with pituitary apoplexy (PA).Methods: Multicenter retrospective study of patients presenting with clinical PA in three Spanish tertiary hospitals between 2008 and 2022. The PAS was calculated following the UK Pituitary Apoplexy Guidelines Development Group evaluation grid.<p class="a...

In our country, as in others, there is a lack of data on the success rate of transsphenoidal surgery for producing pituitary adenomas. We evaluated the results reported in TESSPAIN, a retrospective multicenter nationwide project that includes all the TSS performed in the participating centers in the period between 2018 and 2022, both included. Surgical treatment success is defined according to the published criteria for each disease: normal IGF-1 and GH after 75 g of oral gluc...

Surgical factors, in particular a higher volume of operations and a dedicated neurosurgeon, are considered the main determinants of surgical complication rates in transsphenoidal surgery (TSS). We evaluated postoperative complications in a large series of TSS for non-producing adenomas included in TESSPAIN, a retrospective multicenter nationwide registry. All TSS performed at the 29 participating centers between 2018 and 2022 were included. Globally, 1421 non-producing pituita...