Endocrine Abstracts

Objective: Preoperative iodine therapy due to toxic nodular goiter (TNG) is discouraged as iodine may cause an aggravation of hyperthyroidism. In Graves’ disease iodine has been used for a century but little data is available on iodine treatment in TNG. We aimed to examine if a short course of iodine treatment is safe to administer in TNG.Method: 20 patients with TNG with persistent subclinical to mild hyperthyroidism were included at our tertiary c...

Background: The prescription of triiodothyronine (T3) for hypothyroidism is increasing worldwide, however, long-term effects of its use are largely unknown. Previous studies have suggested possible association between T3 use and breast cancer. The aim of the study was to examine the effects of T3 use on cancer incidence and mortality.Material: Our sample included the full adult population of individuals living in Sweden with at least three purchases of t...

Background: The nature of adrenal tumors can occasionally be difficult to determine using only laboratory and radiological findings. In those rare cases, obtaining a cytological sample by fine needle aspiration (FNA) can be valuable. Transabdominal ultrasound, endoscopic ultrasound (EUS), and computerized tomography (CT) guided biopsy are the most used methods for obtaining a cytological sample from an adrenal lesion.Methods: Adrenal FNAs performed betwe...

Adrenal tumors (ATs) are uncommon in children and adolescents. The aim of this nation-wide retrospective registry-based cohort study was to characterise the various ATs in this population and demonstrate their differences from ATs in adults. All patients under the age of 21 in Sweden with verified adrenal lesions according to ICD-codes between 2005 and 2019 were identified in linked nation-wide registries. Out of the total 232 patients, 121 (52.2%) were boys, with boy predomin...

Introduction: Pheochromocytomas (PHEO) and paragangliomas (PGL) - (PPGLs) are neuroendocrine tumors derived from chromaffin cells of the adrenal medulla or extraadrenal nonchromaffinic tissue, respectively. PPGLs occur in 0.05% to 0.1% of patients with secondary hypertension. Chromogranin A (CgA) is the main non-specific biomarker of neuroendocrine tumors. It is produced and secreted into the blood by endo- and neuroendocrine cells of various organs (e.g., adrenal glands). The...

Background: The accuracy of the radiological and laboratory findings used to investigate adrenal masses are not optimal and therefore additional investigation methods, such as fine needle aspiration (FNA) are sometimes needed. Different methods are used for obtaining FNA such as endoscopic ultrasound (EUS), transabdominal ultrasound and computerized tomography (CT)-guided biopsy.Methods: Using a search function incorporated in our institutional pathology...

Objectives: Polycystic ovary syndrome (PCOS) and thyroid disorders have separately been linked to adverse pregnancy and neonatal outcomes. Even small variations in thyroid function within the normal range may influence fetal growth. Previous data have shown that metformin-treatment of pregnant women with PCOS reduced late miscarriages and preterm births, and resulted in less decrease of fT4 compared to placebo. Moreover, metformin exposure in utero altered the offspring anthro...

Background: Primary aldosteronism (PA) accounts for 5–10% of all hypertension. In about 30% of PA patients the disease is unilateral caused by an adenoma or rarely unilateral hyperplasia. Cure rate from unilateral adrenalectomy, defined as normalized aldosterone secretion, is high but only 30–35% will obtain complete resolution of hypertension. We have studied pre- and postoperative characteristics potentially important for biochemical cure and normotension after adr...

Background: Hashimoto´s thyroiditis (HT) and Graves´ disease (GD) are known co-aggregate in families, but the magnitude and nature of a shared etiology is unknown. The aim of this study was to estimate the shared genetic influence on these diseases. In addition, we sought to examine if the heritability of HT and GD differs between men and women.Methods: We used national health registries to identify cases of HT and GD in a cohort of 110 814 Swe...

Introduction: Graves’ disease (GD) can negatively affect the quality of life. Research on GD in childhood, accounting for 1-5% of cases, has so far predominantly focused on treatment results. There is limited knowledge about association with other diseases and long-term psychosocial effects.Aims: We aimed to compare disease burden and psychosocial outcomes between childhood/young adult GD patients and unexposed population controls.<p class="abst...