Searchable abstracts of presentations at key conferences in endocrinology

ea0086p56 | Metabolism, Obesity and Diabetes | SFEBES2022

Macrophage-specific SHIP2 knockdown mice display sex-dependent liver steatosis

Chabrier Gwladys , Pineda-Torra Ines , Yuldasheva Nadira , Kearney Mark , Gage Matthew

Background: Non-alcoholic fatty liver disease (NAFLD) is a spectrum of progressive liver diseases driven in part by macrophages, occurring in the absence of excessive alcohol consumption that ranges from simple steatosis to non-alcoholic steato-hepatitis (NASH), ultimately progressing to fibrosis/cirrhosis and hepatocellular carcinoma. NAFLD is associated with insulin resistance and confers an increased risk of cardiovascular disease. Pre-menopausal women are protected against...

ea0094op2.1 | Metabolism, Obesity and Diabetes | SFEBES2023

Insulin resistance in macrophages impacts cholesterol biosynthesis and interferon gene expression and reduces foam cell formation capacity

Chabrier Gwladys , Pineda-Torra Ines , Hobson Sam , Yuldasheva Nadira , Kearney Mark , Schurmans Stephane , Gage Matthew

Background: Insulin resistance and ageing are risk factors for the development of type 2 diabetes and atherosclerosis. Insulin signalling in macrophages affects their inflammatory responses and foam cell formation capacity, yet the mechanisms linking these remain unclear. Recent evidence has emerged linking macrophage lipid metabolism and inflammatory response such as an interferon-cholesterol pathway flux axis. Insulin has been shown to directly regulate chol...