ea0029p553 | Diabetes | ICEECE2012
Solomon G
, Monsonego-Ornan E
, Chapnik N
, Smith E
, Froy O
, D'Alessio D
, Gertler A
Obesity and its major consequence, type II diabetes mellitus (T2DM), is epidemic throughout Western society. T2DM accounts for 95% of the diabetes worldwide. One limitation to the development of new diabetes treatments has been a lack of effective animal models to use in research. There are no rodent models that recapitulate the pancreatic β-cell lesions of humans with T2DM. Moreover, animal models of obesity either require overfeeding which is expensive and takes weeks t...