ea0094p65 | Metabolism, Obesity and Diabetes | SFEBES2023
Yu Vanessa
, Yong Fiona
, Marta Angellica
, Khadayate Sanjay
, Bhattach Supriyo
, Chen Keran
, Georgiadou Eleni
, Parveen Nazia
, Marselli Lorella
, De Luca Carmela
, Suleiman Mara
, Whilding Chad
, Marchetti Piero
, Dhawan Sangeeta
, Withers Dominic
, Rutter Guy
, Millership Steven
Subpopulations of beta cells dictate overall pacing of insulin secretion across the islet and therefore the control of glycaemia. Functional beta cell subpopulations also exist in human islets and have an altered subtype distribution in type 2 diabetes. However, the molecular control of the establishment and maintenance of beta cell hierarchy is poorly understood. We hypothesised that the epigenome would govern this heterogeneity. We have identified a novel subpopu...