ea0038p355 | Reproduction | SFEBES2015
Johnstone Edward
, Al-Saghir Khiria
, Tan Cherlyn
, Adlam Daman
, Westwood Melissa
Failure of trophoblast invasion and remodelling of maternal blood vessels leads to the pregnancy complication pre-eclampsia (PE). Metabolomic profiling of placentas from such pregnancies has identified deranged sphingolipid metabolism as one of the pathways altered in PE. In other systems, the bioactive sphingolipid, sphingosine-1-phosphate (S1P) controls cell migration therefore this study aimed to determine its effect on extravillous trophoblast (EVT) function.<p class="...