Searchable abstracts of presentations at key conferences in endocrinology

ea0090p116 | Endocrine-related Cancer | ECE2023

Impact of Gender on Treatment Decisions and Outcome in Patients with Neuroendocrine Neoplasms

Beck Julia , Siebenhuner Alexander , Wild Damian , Christ Emanuel , Refardt Julie

Introduction/Background: Gender differences affect the treatment of several diseases in both male and female patients. However, the influence of gender on treatment decisions and outcome in neuroendocrine neoplasms (NENs) has scarcely been investigated. Aims: Comparison of tumor characteristics, treatment decisions and outcome of patients with NENs, stratified by genderMaterial and Methods: Retrospective analysis of the SwissNET co...

ea0090p119 | Endocrine-related Cancer | ECE2023

Improvement of Lung NET Management through standardized Care – a Swiss nationwide observational Study

Schmidlin Moira , Sadowski Samira , Siebenhuner Alexander , Wild Damian , Christ Emanuel , Refardt Julie

Introduction/ Background: Typical (TC) and atypical carcinoids (AC) are the most common neuroendocrine tumors (NETs) of the lung. Being a rare disease, the management of these tumors varies widely among Swiss centers. The impact of guidelines introduced in 2015 is unknown.Aims: Comparison of the management of Swiss patients before and after the publication of the expert consensus of the European Neuroendocrine Tumor Society (ENETS) in 2015.<p class="...

ea0037ep1115 | Endocrine tumours | ECE2015

Multifocal insulinomas (insulinomatosis) in GLP-1-receptor PET/CT

Jenni Stefan , Antwi Kwadwo , Fani Melponemi , Wild Damian , Heye Tobias , Gloor Beat , Perren Aurel , Christ Emanuel

Introduction: Apart from occurring sporadically, insulinoma within the framework of multiple endocrine neoplasia 1 (MEN-1) is well known. The rare presence of multifocal insulinomas has recently been assigned a separate entity (insulinomatosis). The difficulty of localising insulinomas may be improved by GLP1-receptor imaging.Case report A 48-year-old woman had been treated for suspected epileptic seizures for 2 years (lamotrigine). During another such e...

ea0052p36 | (1) | UKINETS2017

Phase 1/2 open-label trial to assess the safety and preliminary efficacy of 177Lu-OPS201 as peptide receptor radionuclide therapy in patients with somatostatin receptor-positive, progressive neuroendocrine tumours

Nicolas Guillaume , Baum Richard , Herrmann Ken , Lassmann Michael , Hicks Rodney , Haug Alexander , Navalkissoor Shaunak , Oberwittler Heike , Wang Tiffany , Wild Damian

Introduction: Peptide receptor radionuclide therapy (PRRT) with radiolabelled somatostatin receptor (SSTR) agonists is highly effective and has become an integral part of neuroendocrine tumour (NET) treatment. However, tumour uptake and tumour-to-tissue dose ratios may be higher with radiolabelled SSTR antagonists than agonists. OPS201 (DOTA-JR11) is a very promising next-generation SSTR antagonist selective for SSTR2 (expressed by NETs). This phase 1/2, international, single-...

ea0063gp226 | Adrenal and Neuroendocrine - Clinical (1) | ECE2019

Evaluation of the CCK-2 receptor agonist 177Lu-PP-F11N for radionuclide therapy of medullary thyroid carcinoma – final Results of the phase 0 ‘Lumed’ Study

Rottenburger Christof , Nicolas Guillaume , McDougall Lisa , Kaul Felix , Cachovan Michael , Schibli Roger , Geistlich Susanne , Behe Martin , Wild Damian , Christ Emanuel

Objectives: Despite the introduction of new molecular targeted therapies, there is still an unmet need for an effective systemic therapy for advanced medullary thyroid carcinoma (MTC). As MTC expresses cholecystokinine-2 (CCK-2) receptors at a high incidence and density, targeting the CCK-2 receptor with radiolabelled gastrin analogues is a potential approach for radionuclide therapy. Unfortunately, kidney and bone marrow toxicity precluded therapeutic applications of CCK-2 re...

ea0049gp185 | Pituitary &amp; endocrine Tumours | ECE2017

Localization of benign insulinomas using glucagon-like peptide-1 receptor (GLP1-R) SPECT/CT and PET/CT and MRI in a prospective clinical study

Antwi Kwadwo , Fani Melpomeni , Heye Tobias , Nicolas Guillaume , Merkle Elmar , Reubi Jean Claude , Gloor Beat , Wild Damian , Christ Emanuel

Purpose: We aim at prospectively comparing the detection rate of GLP1-R PET/CT vs GLP1-R SPECT/CT vs standardized contrast enhanced 3T-MRI in patients with suspected insulinoma.Methods: 40 patients with neuroglycopenic symptoms due to endogenous hyperinsulinemic hypoglycemia were enrolled.3T-MRI was performed. Afterwards patients received SPECT/CT after injection of 111In-DOTA-exendin-4 and PET/CT after injection of <sup...

ea0041ep590 | Endocrine tumours and neoplasia | ECE2016

Localization of benign insulinomas using glucagon-like peptide-1 receptor (GLP1-R) SPECT/CT and PET/CT in a prospective clinical study

Antwi Kwadwo , Fani Melpomeni , Heye Tobias , Nicolas Guillaume , Merkle Elmar , Reubi Jean Claude , Gloor Beat , Wild Damian , Christ Emanuel

Purpose: The aim of our study is to compare the detection rate of GLP-1R PET/CT and GLP-1R SPECT/CT in patients with a biochemically proven endogenous hyperinsulinemic hypoglycemia. Preliminary results of an ongoing study are reported.Methods: Thirty-three patients (25 females, 8 males, age range 18–80 years, mean 49 years) with neuroglycopenic symptoms due to endogenous hyperinsulinemic hypoglycemia were enrolled (ClinicalTrials.gov, NCT02127541).<...

ea0022p404 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Ectopic insulin secretion from distant metastasis or ectopic metaplasia after total pancreatectomy for ACTH-secreting endocrine pancreatic tumor revealing a Von Hippel Lindau disease

Vantyghem Marie-Christine , Wild Damian , Neraud Barbara , Nghi-Beron Amandine , Raverdy Violeta , Steinling Marc , Wemeau Jean-Louis , Pattou Francois

Von Hippel Lindau disease (VHL) induces tumors of kidneys, central nervous system, pancreas and paragangliomas We report one case where ectopic Cushing syndrome revealed VHL. A 19-year old was referred for hirsutism and spaniomenorrhea revealing an ACTH-dependent Cushing syndrome. Mineralocorticoids, calcium metabolism, chromogranine A, calcitonine, pancreatic hormones and urinary 5-HIA were normal. Blood nor- and metanephrine were 5.12 μg/l (n<5) and 0.92 &#95...

ea0056gp234 | Thyroid Cancer - Diagnostics &amp; Treatments | ECE2018

Title Evaluation of the CCK-2-receptor agonist 177Lu-PP-F11N for peptide receptor radionuclide therapy (PRRT) of medullary thyroid carcinoma - First results of a phase 0 ‘Lumed’ Study

Rottenburger Christof , Nicolas Guillaume , McDougall Lisa , Kaul Felix , Cachovan Michael , Schibli Roger , Geistlich Susanne , Behe Martin , Wild Damian , Christ Emanuel

Objectives: There is still an unmet need for an effective systemic therapy for advanced medullary thyroid carcinoma (MTC). Targeting the cholecystokinine-2 (CCK-2) receptor with radiolabelled gastrin analogues is a potential approach for radionuclide therapy, as MTC expresses CCK-2 receptors at a high incidence and density. Unfortunately, kidney and bone marrow toxicity precluded therapeutic applications of CCK-2 receptor specific compounds until now. The aim of this prospecti...

ea0063gp1 | Adrenal and Neuroendocrine - Tumour | ECE2019

68Ga-exendin-4 PET/CT detects insulinomas in patients with hypoglycemia in multiple endocrine neoplasia type 1

Antwi Kwadwo , Nicolas Guillaume , Fanis Melpomeni , Heye Tobias , Pattou Francois , Grossman Ashley , Chanson Philippe , Reubi Jean Claude , Perren Aurel , Gloor Beat , Vogt Deborah , Wild Damian , Christ Emanuel

Context: Surgical intervention is advised in patients with multiple endocrine neoplasia type-1 (MEN-1) with non-functioning pancreatic neuroendocrine tumors (PanNET) and a size ≥20 mm. However, functioning PanNET such as patients with endogenous hyperinsulinemic hypoglycemia (EHH) due to (one or multiple) insulinomas should be treated surgically independent of size. Reliable preoperative localization of insulinomas is critical for surgical strategy.<p class="abstext"...