Endocrine Abstracts

C reactive protein is a sensitive marker of subclinical inflammation. C-reactive protein is associated with obesity, diabetes mellitus and increased cardiovascular risk. The mechanism of elevated CRP levels could have connections with insulin resistance. Inflammation seems to have significant role in pathogenesis of diabetes and cardiovascular disease. The aim of this study is to show that the subjects with greater insulin resistance, measured by HOMA-IR have higher levels of ...

Fat tissue is highly active tissue, both metabolically and as endocrine tissue, which produced large number of bioactive peptides, known as adipocitokines. They seem to contribute in pathogenesis of obesity, insulin resistance, diabetes mellitus type 2, hypertension, hyperlipidemia, and vascular disease. Adipocitokines and low grade inflammation could be connection between obesity and coexisting diseases. This is the reason we believe that body weight reduction could have posi...

Background and Aims: Insulin glargine is a long acting insulin analog that mimics normal basal insulin secretion without pronounced peaks. The aim of this study was to compare insulin glargine with NPH insulin for basal insulin supply in patients with type 1 diabetes.Materials and Methods: A total of 48 type 1 diabetics (mean age 27 yr, BMI 23,1 kg/m2) on long term intensive insulin therapy (IIT) were randomized into 3 different regimens of ba...

Background and aims: Many obese patients with type 2 diabetes mellitus (T2DM) are not adequatly controlled with oral antidiabetic therapy (OAD), even with combination between metformin and sulfonylurea (SU). When OADs no longer maintain good glycaemic control in obese T2DM, it is necessary to add insulin therapy. The aim of this study is to compare the effect of adding premixed insulin aspart 30(BIAsp30) vs. premixed human insulin 30/70 (BHI30) to support metformin therapy in ...

Background and aims: Metformin is the drug of first choice in obese patients with type 2 diabetes (T2DM), but in some patients it is not possible to achieve good glycaemic control by using metformin only. Starting from a fact that T2DM is a heterogeneous disorder due to the interaction of impaired early insulin secretion and peripheral insulin resistance, the aim of the present study was to evaluate and compare the efficacy of repaglinide vs. glimepirid on glycaemic control of...

Background: The most common method for evaluation of a suspicious thyroid nodule is a fine needle aspiration biopsy (FNAB). Together with ultrasound examination, thyroid scanning using pertechnetate and functional thyroid testing it helps in distinguishing between benign and malignant disease.Objective: Aim of this study is to assess accuracy of FNAB in the diagnostic evaluation of thyroid nodules.Patients: We retrospectively analy...