ea0034p366 | Steroids | SFEBES2014
Kelly Daniel
, Akhtar Samia
, Muraleedharan Vakkat
, Sellers Donna
, Brooke Johnathan
, McLaren David
, Jones Hugh
Introduction: There is a strong association between testosterone deficiency and the incidence of type 2 diabetes (T2D) in men. Physiological testosterone replacement (TRT) improves insulin resistance and glycaemic control in hypogonadal men. The mechanism by which testosterone mediates these beneficial actions are unknown but may be due to an effect on major metabolically active tissues such as liver and muscle. This study investigates the expression of key regulatory targets ...