Endocrine Abstracts

Introduction: Diabetes is increasing its prevalence as an enhancement of treatment options arises and mortality declines. Pancreas transplantation has been postulated as one of them, specifically indicated for cases with end-stage renal failure where kidney transplantation is required besides. It has been analysed whether there is a clinical benefit in terms of quality of life (QoL) in patients undergoing pancreas-kidney transplantation (PKT) compared to dyalisis population or...

omatostatin, originally isolated from ovine hypothalami in 1973, and cortistatin, identified a decade ago in amphibians and then in human and rodents, are two highly related peptides thought to derive from a common ancestor gene. Owing to their high structural homology, both peptides bind with similar affinity to the five so-called somatostatin receptors (sst1-sst5), and exert virtually undistinguishable effects on several physiological targets, including inhibition of endocri...