ea0021p305 | Pituitary | SFEBES2009
Newey Paul
, Dyar Rebecca
, Nesbit Andrew
, Javid Mahsa
, Walls Gerard
, Reed Anita
, Bowl Michael
, Thakker Rajesh
MicroRNAs (miRNAs) are small non-coding RNAs of ~22 nucleotides that negatively regulate gene expression through imperfect base pairing to the 3′ untranslated regions (UTRs) of target mRNAs. We have investigated the role of the miR-15amiR-16-1 cluster in pituitary tumourigenesis, as it functions in other cancers as a tumour suppressor via regulation of the cell-cycle regulator cyclin D1. We have used two approaches: 1) in vitro studies examinin...