Endocrine Abstracts

Objective: To determine the incidence of endometrium pathology in women with autoimmune thyroid pathology and history of reproductive losses, including an assessment of histological images and immunohistochemical (IHC) analysis of the endometrial receptor status.Materials and methods: A prospective cohort study included a clinical and instrumental examination of 84 women aged 18 to 45 years with a history of 1 to 3 consecutive pregnancy losses. Patients ...

Context: Autoimmune thyroid pathology can lead to serious complications of pregnancy and can be combined with generalized autoimmune imbalance, in particular, in the endometrium. The imbalance in the regulation of the immunocompetent cells activity and the increase of cytokines production are one of the reasons for the failed implantation or disruption of embryo development with future consequencesObjective: To assess the role of paracrine factors (expre...

The complex study of the endometrium, in particular, immunohistochemical (IHC), allows to determine the state of steroid receptivity and allows to choose the optimal way of examination in women with autoimmune thyroid diseases and miscarriages.Aim: To evaluate IHC expression of steroid receptors (ERα, ERβ, PR) in endometrium in women with a history of reproductive loss and autoimmune thyroid diseasesMaterials and methods:...

Dysregulation of the neuroendocrine system is a key element in the pathogenesis of polycystic ovary syndrome (PCOS). Orexins (hypocretins) are a new class of hypothalamic neuropeptides that influence sleep-wake rhythms and the state of energy metabolism. In addition, their receptors expresses in peripheral tissues, including the endocrine system. Data have emerged on the role of orexins in the regulation of the reproductive system and, in particular, ovulation, through a direc...

Introduction: Acromegaly can be asymptomatic for a long time and morbid obesity can mask typical clinical signs (facial disfigurement, large hands and feet) and even severe disorders, such as hypopituitarism, cardiomyopathy, respiratory dysfunction, sleep apnea, atherosclerosis, endothelial dysfunction, arthropathy, prediabetes/diabetes, dyslipidemia and mineral dysmetabolism. Menstrual irregularity and infertility combined with headaches are among the earliest issues a patien...