Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep1258 | Clinical Cases–Thyroid/Other | ECE2015

A rare cause of syndrome of inappropriate antidiuretic hormone

Niyazoglu Mutlu , Hatipoglu Esra , Kaya Burcugul , Gundogdu Sadi

Introduction: Acute intermittent porphyria (AIP) is an autosomal dominant disorder resulting from partial deficiency of the haeme biosynthetic enzyme porphobilinogen deaminase.Case report: A 17-year-old female presented with progressive abdominal pain. She had history of recurrent abdominal pain and darkening in urine colour. She was on lansoprazol and metaclopramide, initiated 2 days earlier. She did not have additional personal or relevant family histo...

ea0035p869 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

A case with acromegaloidism

Kadioglu Pinar , Kalfa Melike , Hatipoglu Esra , Gundogdu Sadi

Introduction: Acromegaloidism is characterized by features of acromegaly without excessive GH secretion.Case report: A 24-year-old male presented with acral enlargement and bilateral non-inflammatory wrist and ankle pain. He had coarse facial features, prominent clubbing, enlarged hands and feet. BMI was 21.3 kg/m2. He did not have a relevant personal and family history. He was not on any medication. Due to his acromegaloid appearance he was r...

ea0090ep716 | Pituitary and Neuroendocrinology | ECE2023

Coexistence of acromegaly and Xanthomatous Hypophysitis

Uzman Rukiye Dilara Tekin , Burhan Sebnem , Dogukan Fatih Mert , Kocak Burak , Hatipoglu Esra Suheda , Niyazoglu Mutlu

Introduction: Hypophysitis is a rare pituitary inflammation due to primary and secondary causes. Xanthomatous hypophysitis is the rarest subtype and described with lipid-laden cystic areas, transparent cytoplasmic and lipid-laden histiocytes and foamy (xanthomatous) histiocytes. Although the etiology of xanthomatous hypophysitis is not clearly known, it has been suggested to develop as a result of autoimmune cause or inflammatory process of infiltration of cyst components from...

ea0041gp166 | Pituitary - Clinical (1) | ECE2016

Auditory changes in acromegaly

Tabur Suzan , Korkmaz Hakan , Baysal Elif , Hatipoglu Esra , Aytac Ismail , Akarsu Ersin

Introduction: Certain sensory system functions are affected somehow in acromegaly, however auditory complications have not been identified in detail yet. It is possible that widespread changes in acromegaly may also affect auditory system. We aimed to determine the changes involving auditory system in cases with acromegaly.Methods/design: Otological examination of 41 cases with acromegaly (active n=22, inactive n=19) were compared with ...

ea0073aep705 | Thyroid | ECE2021

Graves’ disease and isolated langerhans cell histiocytosis, a rare case presentation

Emre Uzun Yusuf , Eroglu Ersan , Kayikci Omur , Ersozlu Ilker , Suheda Hatipoglu Esra

IntroductionLangerhans cell histiocytosis (LCH) is a rare monoclonal disease characterized by abnormal proliferation and accumulation of bone marrow-derived Langerhans cells in various tissues. Heterogeneous collections of Langerhans cells with neutrophils, lymphocytes, eosinophils, histiocytes and Birbeck granules are observed in biopsy materials. Endocrinologic features of LCH are usually due to posterior pituitary involvement. Thyroid infiltration is ...

ea0099ep569 | Pituitary and Neuroendocrinology | ECE2024

Neurosteroids and cognition in cushing disease

Burhan Sebnem , Akpınar Ebubekir , Eyupoglu Sevim , Erkan Buruc , Niyazoglu Mutlu , Hatipoglu Esra

Objective: Neurosteroids, a unique hormone group, are recognized for their impact on cognitive processes. The primary objective is to assess the correlation between cognitive function and NS levels in cases of Cushing’s disease and a control group of nonfunctional pituitary adenoma (NFPA).Design: The study comprised 26 individuals diagnosed with Cushing’s disease (CDG), while a control group (CG) consisted of 14 age-gender matched participants ...

ea0035p879 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Comprehensive geriatric assessment of elderly cases with acromegaly

Hatipoglu Esra , Yuruyen Mehmet , Keskin Ela , Niyazoglu Mutlu , Yavuzer Hakan , Doventas Alper , Erdincler Deniz Suna , Beger Tanju , Gundogdu Sadi

Introduction: We aimed to determine changes in geriatric assessment of cases with acromegaly.Methods: 26 elderly cases with acromegaly (controlled/uncontrolled: 15/11, F/M: 17/9) were included. 20 age, gender and BMI matched cases without acromegaly composed control group (CG) (F/M: 10/10). Presence of concomitant diseases and educational level were not different between the groups. Cognitive functions were evaluated with Mini Mental State Exam (MMSE), a...

ea0099ep353 | Pituitary and Neuroendocrinology | ECE2024

Diagnosing acromegaly using artificial intelligence

Burhan Sebnem , Zahit Yılmaz Mehmet , Sokmen Benginur , Tekin Uzman Dilara , Karaali Zeynep , Niyazoglu Mutlu , Hatipoglu Esra

Objective: Even with advancements in diagnostic techniques, acromegaly continues to be diagnosed late. This study aimed to employ deep learning methods to automatically identify acromegaly disease from images of faces, hands, and feet to enhance the efficiency of disease detection.Design: Cross-sectionaly single-center study with deep learningMethods: The study included 71 acromegaly patients and 65 healthy controls. All patients h...

ea0099ep1028 | Pituitary and Neuroendocrinology | ECE2024

Neurosteroids in human pituitary adenomas

Hatipoglu Esra , Akpinar Ebubekir , Erkan Buruc , Yalcinkaya Selahattin , Aksoy Şeyma , Burhan Sebnem , Gunaldı Omur , Tanriverdi Osman , Niyazoğlu Mutlu

Neurosteroids refer to hormones with a steroid structure and, their synthesis pathways are identical to those of traditional steroids. However, neurosteroids are generated denovo in the central and peripheral nervous systems and utilize cell surface receptors. Few animal studies indicated synthesis of NS in pituitary. Presence of neurosteroids in human pituitary adenomas(PAs) has yet to be assessed. This is preliminary data of an ongoing study. Seventyseven specimens from huma...