Endocrine Abstracts

Background: Spinal muscular atrophy (SMA) is hereditary, degenerative, neuro-muscular disease of lower motor neurone that leads to muscle weakness and atrophy. Several metabolic disturbances such as impaired glucose tolerance (IGT), insulin resistance (IR), hypoglycaemia and dyslipidaemia can be present. Most studies were done in children, with more severe forms of SMA. We aimed to assess body composition, IR, glucose and lipid metabolism in adult patients with SMA type 2 and ...