ea0037gp.13.02 | Diabetes and obesity – Translational cardiovascular and obesity | ECE2015
Aerts Evi
, Zegers Doreen
, Sorber Laure
, Beckers Sigri
, Verrijken An
, Massa Guy
, Hoorenbeeck Kim Van
, Verhulst Stijn L
, Gaal Luc F Van
, Hul Wim Van
Objective: NPY2R is a G-protein-coupled receptor which is highly expressed in orexigenic NPY/AGRP neurons within the arcuate nucleus, a major integrator of appetite control in the hypothalamus. Genetic evidence coming from animal and association studies, has identified NPY2R as a candidate gene for obesity. Therefore we have designed an extensive mutation and CNV-analysis investigating the prevalence of genetic and structural variation in NPY2R.Design an...