Endocrine Abstracts

Hyponatremia is the electrolyte disorder most commonly encountered in hospitalized patients. The prevalence and characteristics of patients admitted with hyponatremia are analyzed in this study.Description of methods/design: cross sectional study is carried out at the University General Hospital of Valencia, comprising a population of 350,000. 681 of the 30676 patients admitted during the period from January 2014 to December 2015 had hyponatremia include...

Introduction: HNF-1β maturity-onset diabetes of the young (MODY5) is uncommon, nevertheless accurate diagnosis guides individualized management and informs prognosis in probands and relatives.Objective: To emphasize the importance of the appropriate use of clinical, biochemical and genetic investigations for the correct classification of diabetes etiology.Case-report: A 35-year-old overweight Latin-American male was diagnosed ...

Introduction: Maternally inherited diabetes and deafness (MIDD), is a rare entity. Most commonly, it is related to a point mutation in the mitochondrial DNA (mtDNA) at position 3243 (m.3243A>G) encoding the gene for tRNA. A high index of suspicion is required for the diagnosis due to a wide heterogeneity in its clinical presentation which reflects different levels of mutated mtDNA among mitochondria in a given tissue (heteroplasmy). Thyroid cancer risk has never been speci...

Background: Acute intermittent porphyria (AIP) is an inherited autosomal dominant disorder characterized by hepatic deficiency of hydroxymethylbilane synthase (HMBS)/porphobilinogen deaminase (PBGD), the third enzyme of the heme synthesis pathway. Hyponatremia is one of the main presenting symptoms and it is thought to be related to an inadequate secretion of ADH (SIADH). Since AIP is an uncommon disease, there is little information about how AIP related hyponatremia responds ...

Introduction and aim: The current population is experiencing an increase in life expectancy, with a consequent change in the demographic structure of the society. It is common, therefore, to find elderly patients with pituitary neuroendocrine tumors (PitNET) in our usual clinical practice. Currently, there are no specific recommendations for treatment and data of outcomes in elderly are scarce. The aim of our study was to compare the clinical characteristics and surgical outco...

Background: Although the majority of cases of hyperandrogenism in postmenopausal women are due to functional causes, the sudden appearance of a severe and rapidly progressive condition, especially if associated with signs of virilization and defeminization, requires always ruling out the existence of an androgen-producing tumor at both the adrenal and ovarian levels. Etiological diagnosis can be difficult because ovarian tumors are not easily demonstrable by imaging.<p cla...

Introduction: Amiodarone is an antiarrhythmic drug whose high iodine content may influence thyroid function. The first line treatment of amiodarone-induced hyperthyroidism (AIH) is mainly medical. Plasmapheresis has been used in cases of antithyroid intolerance or refractory hyperthyroidism, although clinical experience is poor.Clinical case: We present a case of a patient with structural heart disease and severe AIH refractory to medical treatment who r...