ea0056p1057 | Thyroid (non-cancer) | ECE2018
Molnar Ildiko
, Szentmiklosi Jozsef A
, Gesztelyi Rudolf
, Somogyine-Vari Eva
Antithyroid drugs represent mainly the first choice therapy in hyperthyroid Graves disease. Their therapeutical ineffectiveness can lead to the onset or the severity of ophthalmopathy associated with Graves disease. Type 2 5-deiodinase enzyme (DIO2) plays a crucial role besides type 1 5-deiodinase enzyme in the development of Graves hyperthyroidism. Anti-thyroid drugs inhibit the activity of both type 5-deiodinases blocking the synthesis of ...