Endocrine Abstracts

Introduction: Paradoxical increase of growth hormone after glucose load (PR) and its clinical significance remain the focus of researchers. Different cut off points for diagnosis of PR are used in the literature. Aim : Our aim was to investigate 3 different definitions of PR and their clinical implications.Material and Methods: We analyzed 116 consecutive patients diagnosed with acromegaly in 2012-2022. We included 89 patients with...

Introduction: Somatotroph Pituitary Neuroendocrine Tumor’s (sPitNET) signal intensity in T2-weighted MR images (SI) was reported as prognostic marker for tumor’s aggressiveness and poor response to 1st generation somatostatin analogs (SSA). Tumors are arbitrary divided into 3 groups: hyperintensive (HYPER), isointensive (ISO) and hypointensive (HYPO). Aim: Our aim was to quantitatively assess SI of sPitNETs and investigate its clinic...

Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumours, which derive from the chromaffin cells of the adrenal medulla or extra-adrenal sympathetic and parasympathetic ganglia. About 15-20% of those neoplasms could present malignant course. Prediction of PPGL metastatic potential still remains a great clinical challenge, since the sensitivity and specificity of proposed prediction systems are not satisfactory. We performed a retrospective database search for ...

Introduction: 2-[18F]FDG PET/CT, commonly used for neoplastic lesions detection, also allows assessment of the severity of the inflammatory processes. Moreover, glucose uptake in spleen and bone marrow may be a useful biomarker of systemic inflammation. Patients with Cushing syndrome demonstrate many metabolic changes involving muscles and fat tissue. Some mechanisms are known, but their relationship to glucose metabolism is not well investigated. Our study aimed to correlate ...

Aim: To investigate T2-signal intensity (SI) and histopathological characteristics of the somatotroph PitNETs (S-PitNET).Methods: 41 out of 109 consecutive patients with newly diagnosed acromegaly and available histopathological results were included. 36 results contained the electron microscope examination. Tumors were divided into 3 SI groups: hyperintensive (HyPER), isointensive (ISO) and hypointensive (HyPO). SI was assessed qualitatively using Visua...

Adrenal haemorrhage is a rare, usually life-threating complication, most commonly connected with primary or metastatic adrenal tumour. Among them pheochromocytoma is the most common cause of spontaneous adrenal bleeding and accounts for nearly 50% of cases. We performed a database search for pheochromocytoma patients, diagnosed and treated in Endocrinology Department, University Hospital in Cracow from 2005 to 2021. 206 patients with pheochromocytoma were identified. Subsequen...