Endocrine Abstracts

Annona squamosa has been shown to have anti-diabetic properties, although the underlying mechanisms are not fully known. In the present study, ethanol extract A. squamosa (EEAS) leaf were investigated in vitro and in vivo, to elucidate the mechanism underlying anti-diabetic actions. EEAS significantly (P<0.05–0•001) increased insulin release 2.2-5.5-folds at 5.6 mM/16.7 mM glucose at concentrations between 8-5000µg/ml from BRIN-BD1...

The prevalence of type 2 diabetes (non-insulin dependent diabetes) has been universally acknowledged as a chronic public health concern and the leading cause of mortality on a global scale. Plant-based bioactive compounds have made significant contributions to the management of diabetes mellitus globally. Artocarpus heterophyllus, also known as “kathal” in the subcontinent, is rich in dietary fibre and has traditionally been used as a diabetes remedy. The current stu...