ea0063p201 | Diabetes, Obesity and Metabolism 1 | ECE2019
Anceau Christine Cugnet
, Jehl Alexandre
, Vigouroux Corinne
, Dalle Stephane
, Harou Olivier
, Marchand Lucien
, Lascols Olivier
, Caussy Cyrielle
, Thivolet Charles
, Laville Martine
, Disse Emmanuel
Context: Anti-programmed cell death-1 (Anti-PD-1) antibodies have revolutionized advanced cancer therapy. Anti-PD1 therapy is responsible for immune-related adverse events, with frequent endocrine manifestations. Acquired generalized lipodystrophy (AGL), is a rare disease, thought to be immune-mediated, characterized by loss of adipose tissue and insulin resistance-associated complications. We describe the first case of AGL induced by immune checkpoint therapy.<p class="ab...