Endocrine Abstracts

Insulin resistance (IR) is a condition where beta cells are producing insulin, sometimes in large amounts, but the peripheral targets develop an inadequate response to the hormone. Classically insulin resistance has been associated with pathologic conditions. However, there is also physiological IR, associated with the last period of pregnancy and in different moments of the development. We have previously characterised a period of physiological IR, around the ablactation peri...

Extracellular proteolytic cleavage of insulin receptor (IR) and the generation of soluble insulin receptor (sIR) is a response of the liver and fat associated with physiological conditions and metabolic alterations mainly related to hyperinsulinemia. However, cleavage of this receptor has not been analyzed in skeletal muscle, a central tissue in insulin-mediated glucose homeostasis. This study aimed to analyze the insulin receptor subunits in the gastrocnemius and soleus muscl...

Metabolic syndrome (MS) is a group of signs that increase the risk of developing cardiovascular diseases and type 2 diabetes mellitus (DM2). MS includes at least 3 of these signs: central obesity, dyslipidemia, hypertension, fasting glucose disorders, and insulin resistance. The consumption of sugar drinks, a high-calorie diet, a sedentary lifestyle, and environmental pollutants such as arsenic increase the risk of developing MS. Arsenic affects beta-cell function and insulin ...