ea0026s26.2 | The role of plasma binding proteins in tissue hormone delivery | ECE2011
Holly J M P
, Perks C M
The IGFs are present ubiquitously at very high levels throughout the body and affect virtually every aspect of cell function. These high levels are maintained due to their association with 6 distinct binding proteins (IGFBP-1 to -6) which specifically bind IGFs (but not insulin). The IGFs are not stored within any cells but are stored in the circulation due to their binding to IGFBP-3 which then results in its association with a large glycoprotein, the acid labile subunit (ALS...