Endocrine Abstracts

ACTH deficiency is a rare cause of secondary adrenocortical insufficiency and frequently associated autoimmune-mediated hypothyroidism, but there has been no report associated autoimmune-mediated hepatitis. We present a 36-year-old female with generalized weakness, malaise, hypersomnolence. Investigations showed low albumin, prolonged PT, elevated bilirubin level and abdominal ultrasonography and CT revealed liver cirrhosis with ascites. Though serologic test for hapatopathy w...

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) are important neuropeptides that are structurally related. They have been found to exert many physiological and pathophysiological effects through the activation of three specific receptors: PAC1R, VPAC1R, and VPAC2R. In tetrapods, PACAP and VIP are potent agonists to VPAC2R. In teleosts, we have previously identified a PHIR in goldfish which shares high level of sequence similarity ...

Introduction: Thyroid function tests (thyroid hormones and thyreotropin) are frequently used by physicians all over the world. The interpretation is usually quite simple and straight-forward, however sometimes there is a strange discrepancy between the laboratory findings and clinical presentation. There are several potential explanations to this discrepancy and interference in laboratory assay may be one of them.Observation: We present a case of a 73-ye...

Objective: Impaired cognitive function has been demonstrated in adults with GH deficiency (GHD) and acromegaly by using different neuropsychological tests. P300 ERP application is a well established neurophysiological approach in the assessment of cognitive function. However the comparison of the P300 ERPs between GHD and GH excess have not been done yet. The present study was designed to investigate the effects of GHD and acromegaly on cognitive function by using P300 ERPs.</...