Endocrine Abstracts

Nutrient sensors mediating the stimulatory effects of food-derived carbohydrates and lipids on incretin and insulin secretion have been widely studied. However, mechanisms underlying amino acid regulation of those processes remain poorly understood. GPR142 was recently reported to be highly expressed in pancreatic beta cells and selectively activated by L-Tryptophan (L-Trp). Moreover, synthetic GPR142 agonists were demonstrated to stimulate glucose-dependent insulin secretion ...

Background: Cardiovascular disease (CVD) is the leading cause of death in persons with type 1 diabetes (T1DM). However, there are no CVD-risk prediction models for this population in widespread use and those developed from general population and type 2 diabetes have been shown to underestimate CVD-risk in T1DM. Recently, the Steno Type 1 Risk Engine (ST1RE) was developed for predicting CVD in a cohort of T1DM persons without clinical CVD. We investigate the relationship betwee...

This is a 38-year-old male, a regular user of a gym with the sole purpose of improving his physical performance and muscular strength and habitual consumer of hyperproteic dietary supplements. Among his PAs he denies toxic habits, and highlights the removal of the right testicle in childhood. Consultation for decreased desire and sexual potency, together with pain and turgor in the left breast; hair loss at the frontal level, in analytic carried out by the Primary Care Physici...

Background: The fetal insulin hypothesis proposes that low birth weight, insulin resistance, and decreased insulin secretion in adulthood are genetically mediated. Babies with low birth weight have higher morbidity and mortality risk in adulthood. However, this situation could also occur in children with adequate weight at birth with genetic risk factors. The polymorphisms rs11708067 in ADCY5 and rs7754840 in CDKAL1 have been associated with low birth weight,...

Surgical factors, in particular a higher volume of operations and a dedicated neurosurgeon, are considered the main determinants of surgical complication rates in transsphenoidal surgery (TSS). We evaluated postoperative complications in a large series of TSS for non-producing adenomas included in TESSPAIN, a retrospective multicenter nationwide registry. All TSS performed at the 29 participating centers between 2018 and 2022 were included. Globally, 1421 non-producing pituita...