ea0032oc3.2 | Thyroid | ECE2013
Iwen K Alexander
, Schroder Erich
, Resch Julia
, Lindner Ulrich
, Konig Peter
, Lehnert Hendrik
, Perwitz Nina
, Ibrahim Saleh
, Brabant Georg
Objective: Abnormal mitochondria are well known in oxyphilic thyroid tumors but recent data also confirm profound mitochondrial alterations in other thyroid carcinomas. These changes are linked to the aggressiveness of the tumors. Our group recently demonstrated in an in vivo model, that inhibition of phosphoinositide 3-kinase (PI3K) signalling suppressed the invasive and metastatic behaviour of thyroid cancer cells. Here, we evaluated whether a modulation of PI3K sig...