ea0070aep775 | Pituitary and Neuroendocrinology | ECE2020
Jensen Kolnes Anders
, Astrid Berland Øystese Kristin
, Olarescu Cristina
, Casar-Borota Olivera
, Bollerslev Jens
, Jørgensen Anders
Objectives: To study the effect of epithelial-to-mesenchymal transition (EMT) on hormone expression in gonadotroph non-functioning pituitary neuroendocrine tumours (NF-PitNET).Background: Gonadotroph PitNETs can express FSH and LH or be hormone negative, however they rarely secrete hormones. During tumour development, epithelial cells develop a mesenchymal phenotype. This process is characterised by decreased membranous E-cadherin and translocation of E-...