ea0011p811 | Thyroid | ECE2006
Lisi S
, Maritzen T
, Botta R
, Pinchera A
, Marcocci C
, Jentsch TJ
, Marinò M
Megalin is a member of the LDL receptor family expressed by several epithelial cells where it mediates endocytosis of ligands. In the thyroid megalin is responsible for transcytosis of hormone-poor thyroglobulin (Tg) molecules. This process favors hormone release by preventing hormone-poor Tg to enter the lysosomal pathway, where hormones are cleaved from hormone-rich Tg molecules. Accordingly, megalin KO mice have a distinct thyroid phenotype with primary hypothyroidism. In r...