ea0019p315 | Steroids | SFEBES2009
Chen Jing
, Ramanjaneya Manjunath
, Conner Alex
, Kumar Prashanth
, Brown James
, Johren Olaf
, Lehnert Hendrik
, Stanfield Peter
, Randeva Harpal
Orexin-A and orexin-B orchestrate their diverse central and peripheral effects via two G-protein coupled receptors, OX1R and OX2R, which activate multiple G-proteins. They are involved in a host of physiological processes including, steroidogenesis, appetite control and energy regulation. Whilst some signalling mechanisms have been proposed for individual recombinant orexin receptors in generic mammalian cell types, it is clear that the peripheral effects of orexin are spatial...