ea0065p171 | Metabolism and Obesity | SFEBES2019
Appanna Nathan
, Arvaniti Anastasia
, Gangitano Elena
, Morris Karen
, George Sherly
, Keevil Brian
, Tomlinson Jeremy
, Nikolaou Nikolaos
Metabolic syndrome and its hepatic manifestation, non-alcoholic fatty liver disease (NAFLD), are increasing in prevalence. Steroid hormones are established regulators of metabolic phenotype. 5β-reductase (AKR1D1) is highly expressed in human liver, inactivating steroid hormones, including glucocorticoids and androgens. The human AKR1D1 gene contains 9 exons; six splice variants have been identified and three lead to functional protein isoforms (AKR1D1-001, -0...