ea0054p5 | (1) | NuclearReceptors2018
Tonsing-Carter E
, Kim CR
, Hernandez KM
, Bowie KR
, West DC
, Chandarlapaty S
, Greene GL
, Conzen SD
Early-stage ER+ breast cancer (BC) with high tumor glucocorticoid receptor (GR) expression is associated with improved long term relapse-free survival compared to tumors with low GR expression. In addition, GR activity inhibits ER-mediated BC cell proliferation. We therefore hypothesized that GR and ER engage in nuclear receptor crosstalk to influence pro-proliferative gene expression, thus contributing to a better outcome in ER+/GR+ breast cancer. To understand the mechanisms...