ea0073pep15.2 | Presented ePosters 15: Late Breaking | ECE2021
Venugopalan Vaishnavi
, Al-Hashimi Alaa
, Weber Jonas
, Rehders Maren
, Golchert Janine
, Homuth Georg
, Verrey Francois
, Kirstein Janine
, Heuer Heike
, Schweizer Ulrich
, Wirth Eva
, Brix Klaudia
The thyroid gland functions in supplying thyroid hormones (TH) to the body periphery, which is enabled by cathepsin-mediated thyroglobulin proteolysis and TH translocation across membranes by the Mct8, Mct10, and Lat2 transporters. Previously, we showed that cathepsin K-deficient mice feature normal thyroid phenotypes which is, in part, due to the functional compensation through cathepsin L upregulation that is independent of the classical hypothalamus–pituitary–thyr...