ea0013p213 | AMEND Young Investigator's Award | SFEBES2007
Smith Vicki
, Boelaert Kristien
, Stratford Anna
, James Sally
, Kogai Takahiko
, Franklyn Jayne
, Mccabe Chris
The sodium iodide symporter (NIS) mediates the uptake of iodide into thyroid follicular cells. The pituitary tumor transforming gene (PTTG) is a multifunctional oncogene which stimulates expression of fibroblast growth factor-2 (FGF-2) via PTTG binding factor (PBF). PTTG and FGF-2 inhibit iodide uptake in rat thyroid FRTL5 cells and PTTG and PBF repress NIS mRNA expression and iodide uptake in primary human thyroid cultures. To determine whether this regulation is a direct tra...