Endocrine Abstracts

Introduction: 18F- Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (18F-PSMA PET/CT) is currently used in the evaluation of prostate cancer. Due to increased expression of PSMA in the neovascular endothelial cells of malignant lesions other than prostate cancer, PSMA PET/CT has become of interest to researchers in the management of thyroid cancer. The goal of this study was to evaluate the incidence and clinical signifi...

Introduction: Paragangliomas are rare neuroendocrine neoplasms arising from chromaffin cells in the sympathetic or parasympathetic neural paraganglia that may appear in many places throughout the body. These might be benign or malignant tumors. We report an interesting case of disseminated paraganglioma, the diagnosis of which began with the metastasis to the thyroid gland.Case presentation: A 69-year-old patient with a history of toxic multinodular goit...

Chordomas of the skull base are rare lesions, which account for less than 0.2% of all intracranial tumours. They arise from embryonic remnants of the primitive notochord. They are described as locally aggressive, rarely metastatic tumours with a tendency to frequent relapses. They usually grow slowly with the destruction of the surrounding tissues. The symptoms are very unspecific which is the cause of the delay of the diagnosis. The most common initial symptoms are headaches ...

Introduction: In recent years the growing rate of newly diagnosed papillary tyroid cancers (PTC) has been observed. Nowadays most of PTC are small (mostly <2cm in diameter) with no unfavourable patomorphological features, although the cases of incompletely resected PTC can still be encountered. Incomplete tumour resection, regardless of the presence of microscopic (R1) or macroscopic (R2) disease, after operation, is considered as a high-risk factor for PTC recurrence/pers...

Introduction: An increase in the incidence of differentiated thyroid cancer (DTC) has been observed in recent decades. Despite the excellent prognosis, DTC patients remain on lifelong oncologic follow-up after treatment, due to fear of recurrence.Aim: Was to evaluate the frequency of real recurrence, defined as appearance of structural or biochemical disease after >12 month period of no evidence of disease (NED) in DTC patients.<p class="abstext"...

Introduction: Coexistence of the BRAF V600E and TERT promoter mutations may correlate with more aggressive histopathological features and worse course of the disease. According to the American Thyroid Association (ATA) dynamic risk stratification with modified initial estimated risk based on response- to-therapy and disease course allows individual risk assessment and support clinicians in the appropriate management approach to differentiated thyroid cancer (...

Introduction: The CHEK2 gene is involved in DNA repair. Germline mutations in the CHEK2 gene impair this mechanism, increasing the risk of various cancers, including papillary thyroid cancer (PTC). There are four different mutation variants in the CHEK2 gene in the Polish population: three truncating mutations (1100delC, IVS2+1G>A and del53950) and one missense mutation (I157T).Material: The study included 1,547 PTC patient...