Endocrine Abstracts

Background: Somatic and bi-allelic DICER1 mutations have been reported in subsets of sporadic thyroid tumors, affirming a clear involvement of this gene in the development of thyroid tumors. As a recent study has highlighted associations between DICER1 mutations and macrofollicular patterns, abortive changes, and papillary structures, we aimed to investigate these observations in a bi-institutional cohort.Methods: A total of 61 thyroid lesions (...

De-escalation of thyroid cancer treatment is crucial to prevent over-treatment of indolent disease. However, it also underscores the importance of identifying potential clinically aggressive cases that require completion lobectomy and adjuvant radioiodine therapy. TERT promoter mutations are molecular events closely associated to high-risk thyroid tumors with poor outcome, and may serve as markers for cases at risk of dissemination. In various international guidelines...