Endocrine Abstracts

Monogenic obesity in humans is caused by loss-of-function mutations in several genes, all of which reside in the CNS, and many of which are involved in either leptin signaling or the downstream melanocortin pathway. Ablation of the CNS-specific orphan GPCR Gpr45 in mice is associated with significant monogenic obesity. However, to date, there are no associations between the loss of GPR45 and obesity in human genetics. To that end, we made our own line of Gpr45-/- mice and foun...