ea0029oc13.6 | Adrenal Basic | ICEECE2012
Chrusciel M.
, Vuorenoja S.
, Mohanty B.
, Rivero-Muller A.
, Lei Z.
, Toppari J.
, Li X.
, Huhtaniemi I.
, Rahman N.
We have earlier shown a reciprocal feed-forward amplification link between expression of transcription factor GATA-4 and luteinizing hormone receptor (LHR) during adrenocortical tumorigenesis, and also that chronically elevated LH levels may induce LHR in mice, but not GATA-4. Hereby, our goal was to analyze the consequences of ectopically expressed GATA-4 on murine adrenal cortex in the presence and absence of gonadectomy (GDX) induced elevated LH levels. For this purpose, we...