Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0059pl3 | Society for Endocrinology Medal Lecture | SFEBES2018

Endocrine systems are dynamic: Lessons from the hypothalamic-pituitary-adrenal axis

Lightman Stafford

Biological systems are invariably dynamic, with both stochastic interactions and deterministic processes across multiple timescales ensuring the maintenance of homeostatic regulation and allowing us to adapt to changes in both internal and external environments. It is no surprise therefore that the stress responsive hypothalamic-pituitary-adrenal (HPA) axis shows multiple levels of regulation which come together to regulate oscillating levels of glucocorticoid secretion with b...
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ea0031pl7 | Clinical Endocrinology Trust Lecture | SFEBES2013

The dynamics of hypothalamo-pituitary-adrenal activity

Lightman Stafford

The circadian variation of hypothalamo-pituitary-adrenal (HPA) activity is well recognised, with levels of glucocorticoid rising in anticipation of the activity of the coming day (in humans) or night (in rodents). Less well recognised however, is that in common with many other hormones, both ACTH and corticosteroids are released in a pulsatile pattern – with the largest pulses occurring in the morning in man – explaining the large range of ‘normal’ morning ...
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ea0031pl7biog | Clinical Endocrinology Trust Lecture | SFEBES2013

Clinical Endocrinology Trust Lecture

Lightman Stafford

Stafford Lightman is Professor of Medicine at the University of Bristol and is Director of the Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology. He started his scientific career working on catecholamines and opioid peptides with Leslie Iversen at the University of Cambridge and provided some of the first data linking opioid peptides with the regulation of neurohypophysial function. At this time he also performed some of the first studies demonstrating...
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ea0020pl7 | Implications of adrenal hormone pulsatility | ECE2009

Implications of adrenal hormone pulsatility

Lightman Stafford

The HPA axis has a massive dynamic response rate. At nadir periods (at night in man and during the day in nocturnal rodents) there is a low level of activity which increases up until the circadian peak. This circadian rhythm is made up of an underlying ultradian rhythm of pulsatile glucocorticoid section, with pulse amplitude increasing from the circadian nadir to the circadian peak. Superimposed on this underlying rhythm is, of course, the stress response which can result in ...
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ea0099pl2 | The clinical importance of high resolution, automated, ambulatory measurement of tissue steroids | ECE2024

Stafford Lightman, University of Bristol, UK

Almost all hormonal systems are dynamic with hormones being secreted in various combinations of ultradian, circadian, monthly and even yearly patterns.These patterns have emerged as natural consequences of the multilevel regulation of the hormone axes themselves and in response to environmental conditions such as the light:dark cycle, food availability and temperature. The Hypothalamic-Pituitary-Adrenal (HPA) axis is critical for life and delivers a complex system of pulsed st...
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ea0050p009 | Adrenal and Steroids | SFEBES2017

Using mouse adrenocortical cell lines to investigate how glucocorticoid synthesis is dynamically regulated

Hazell Georgina , Horn George , Lightman Stafford , Spiga Francesca

Glucocorticoid hormones (cortisol in man, corticosterone in rodent; CORT) are vital for maintaining normal homeostasis in multiple systems ((e.g., the cardiovascular, metabolic, and immune systems), and for an optimal response to acute and chronic stress. Plasma CORT is released from the adrenal zona fasciculata (ZF) in response to circulating levels of pituitary-derived adrenocorticotropin hormone (ACTH). ACTH binds to the MC2-receptor on the membra...
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ea0050p009 | Adrenal and Steroids | SFEBES2017

Using mouse adrenocortical cell lines to investigate how glucocorticoid synthesis is dynamically regulated

Hazell Georgina , Horn George , Lightman Stafford , Spiga Francesca

Glucocorticoid hormones (cortisol in man, corticosterone in rodent; CORT) are vital for maintaining normal homeostasis in multiple systems ((e.g., the cardiovascular, metabolic, and immune systems), and for an optimal response to acute and chronic stress. Plasma CORT is released from the adrenal zona fasciculata (ZF) in response to circulating levels of pituitary-derived adrenocorticotropin hormone (ACTH). ACTH binds to the MC2-receptor on the membra...
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ea0059p033 | Adrenal and steroids | SFEBES2018

Prolonged exposur to methylprednisolone disrupt the rat adrenal gland steroidogenic pathway and affect intra-adrenal inflammatory mediators

Spiga Francesca , Zhao Zidong , Li Yanyu , Lightman Stafford

Pharmacological treatment with synthetic glucocorticoids, which are widely prescribed for the treatment of numerous inflammatory and autoimmune diseases, can also affect the way the adrenal gland produces cortisol. Indeed, patients undergoing synthetic glucocorticoid treatment can develop adrenal insufficiency. This condition is characterised by reduced responsiveness of the adrenal to ACTH stimulation, and adrenal crisis/shock can occur in response to acute physiological stre...
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ea0038p393 | Steroids | SFEBES2015

The effects of chronic administration of the synthetic glucocorticoid dexamethasone on memory and learning in the rat

Earl Emma , Kershaw Yvonne , Lightman Stafford , Conway-Campbell Becky

Dexamethasone (DEX) is a widely used synthetic glucocorticoid whose effects are mediated via glucocorticoid receptor (GRs). Synthetic glucocorticoids are widely used in the clinical setting, due to their potent anti-inflammatory actions. However they are associated with numerous systemic side-effects and may also promote cognitive dysfunction, including impaired memory and learning processes in both patients and animal models.Discrete pulses of endogenou...
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ea0025p258 | Pituitary | SFEBES2011

An unusual presentation of thyrotroph adenoma

Raghavan Rajeev , Plaha Puneet , Nelson Richard , Lightman Stafford , Levy Andrew

Background and case: A 38-year-old man presented acutely with left-sided retro-orbital pain, a heavy/numb sensation in his left arm and blurred vision and diplopia on left lateral gaze. Baseline biochemistry, liver function and haematology were normal. His TSH was 3.9 (0.3–4 mU/l) and CRP 92 mg/l (<10). Plain CT head was unremarkable as was the MRI as reported, and atypical migraine was suspected. Vertical diplopia on left lateral gaze and left upper arm paraesthesia ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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