Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1009 | Male Reproduction | ICEECE2012

Rab-like 2 (RABL2) function in male fertility, intra-flagella transport and sperm tail assembly

Lo J. , O'Bryan M.

Infertility affects 1 in 20 Australia men of reproductive age, and for the majority, the causes remain unknown. In an effort to identify addition key pathways and proteins involved in male fertility we undertook a random mouse mutagenesis screen. In the process we identified the Mot1 line which carries a point mutation in the Rabl2 gene. Mot1 homozygous male are sterile, have a reduced daily sperm output, short sperm tails and drastically reduced progressive sperm motil...

ea0032p269 | Clinical case reports – Pituitary/Adrenal | ECE2013

Fountain of steroid deep within: a case report of an ectopic ACTH-producing tumor

Lo Tom Edward , Antonio Imelda , Jimeno Cecilia

Background: Cushing’s syndrome is defined as a hormonal disorder resulting from elevated serum cortisol leading to specific physical and biochemical abnormalities that might be detrimental to life itself. Majority is caused by steroid intake while endogenous sources although representing only a minority of patients often lead to delay in diagnosis. Ectopic ACTH syndrome considered a rare entity are usually found as small cell lung cancer and carcinoid tumors. Rare types o...

ea0032p542 | Endocrine tumours and neoplasia | ECE2013

Endogenous Cushing’s syndrome: the Filipino clinical experience of 19 cases

Edward Lo Tom , Cabradilla Joyce , Jimeno Cecilia

Background and significance: Endogenous Cushing’s syndrome is a rare disease entity approximately 13 cases per million population. In Asia, and specifically in the Philippines incidence is unknown. As well, it’s clinical presentation among Filipinos is not well described. The local epidemiology of obesity, diabetes and hypertension are different from other countries. These conditions are the usual initial differential diagnosis for Cushing’s syndrome. This repor...

ea0037ep838 | Thyroid cancer | ECE2015

Well-differentiated thyroid cancer: the Philippine General Hospital experience

Lo Tom Edward , Uy Abigail , Maningat Patricia Deanna

Well-differentiated thyroid carcinoma (WDTC) is the most common thyroid malignancy. Although, associated with good prognosis, it may have a highly recurrent and fatal outcome in selected groups of patients. Filipinos in particular were reported to be the ethnic group with the highest incidence of thyroid cancer in several studies. Thyroid cancer among Filipinos were also observed to be more aggressive and recurrent in nature. This paper aims to describe the experience of a Phi...

ea0037ep839 | Thyroid cancer | ECE2015

Risk factors for recurrence in Filipinos with well-differentiated thyroid cancer

Lo Tom Edward , Uy Abigail , Maningat Patricia Deanna

The incidence of recurrent well-differentiated thyroid cancer (WDTC) continues to rise as better imaging test and more sensitive monitoring improves disease surveillance. Despite its excellent prognosis, increasing morbidity from recurrent diseases continues to affect long-term outcome of most patients leading to higher medical cost and poorer quality of life. Filipino ethnicity in particular was reported to have the highest incidence of thyroid cancer with a highly aggressive...

ea0037ep840 | Thyroid cancer | ECE2015

Follicular variant of papillary thyroid carcinoma: an intermediate clinical entity

Lo Tom Edward , Uy Abigail , Maningat Patricia Deanna

Follicular variant papillary thyroid cancer (FV-PTC) appeared to be the most common subtype representing between 9 and 22.5% of all PTC cases. With the dramatic increase in thyroid cancer incidence, FV-PTC has also been increasingly diagnosed in recent times. Despite its high incidence, the clinical behaviour, prognosis and outcome of FV-PTC remains controversial and challenging for most physicians. This study aims to compare the disease characteristics of FV-PTC with Classic-...

ea0032p1058 | Thyroid (non-cancer) | ECE2013

Empirical calcium supplements paves way for day surgery complete thyroidectomy

Lo Xina , Tam Tsz Kim , Leong Heng Tat

Post operative hypocalcemia poses significant resistance to early discharge of total thyroidectomised patients. Our institute implemented a new protocol to give empirical calcium and vitamin D supplements since Jan 2012 to prevent symptomatic hypocalcemia and facilitate early discharge. 75 (88.24%) out of 85 eligible cases did not have significant or symptomatic hypocalcemia and can be discharged by within 1 day with only two (2.67%) patients being readmitted electively for si...

ea0019p390 | Thyroid | SFEBES2009

The management of thyroid fine needle aspiration (FNA) cytology samples reported as benign (Thy2): an audit of practice at a teaching hospital

Whitelaw B , Augustin Y , Lo Q , Gilbert J

Introduction: Fine needle aspiration (FNA) is used, in conjunction with clinical assessment and imaging, to assess thyroid nodules for suspected malignancy. Cytological assessment of FNA samples involves both a text report and classification into a diagnostic category Thy1–Thy 5. The cytological category Thy 2 describes a FNA sample assessed to be non-neoplastic. Current BTA guidelines recommend two FNA samples, 3–6 months apart, are obtained to exclude neoplasia.</p...

ea0103p82 | Bone 2 | BSPED2024

Cardiovascular risk and achondroplasia: a systematic review

Lo* Irene , Meti* Shraddha , Mason Avril , Lucas-Herald Angela

Introduction: Achondroplasia, caused by a variant in the fibroblast growth factor receptor 3 (FGFR3) gene is the most common form of disproportionate short stature. It is associated with reduced life expectancy, but it is not clear to what extent cardiovascular disease (CVD) is responsible for this. As such, the primary aim of this systematic review was to identify the prevalence of cardiovascular disease in individuals with this condition.Methods: A sys...

ea0065p296 | Neuroendocrinology | SFEBES2019

In-hospital endocrinology consultation (IHEC) for patients undergoing transsphenoidal resection of sellar masses – is it always necessary?

Ali Imran Syed , Hebb Andrea LO , Massoud Emad , Tramble Lisa , Clarke David B

Patients with sellar masses (SM) undergoing transsphenoidal surgery (TSS) have a significant risk of transient or permanent endocrine dysfunction; therefore, in-hospital endocrinology consultation (IHEC) is recommended for these patients. However, routine assessment of all TSS patients by a specialized team is not feasible outside select centers. We developed an IHEC guide for TSS patients in December 2015 to identify those patients who would require perioperative IHEC. We con...