ea0099p264 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024
Hippolyte Dupuis
, Lucie Stienne
, Georges Lion
, Pascal Pigny
, Vantyghem Marie-Christine
Familial Partial Lipodystrophy Syndromes (FPLD) are rare diseases characterized by partial lack of subcutaneous fat resulting in a severe metabolic syndrome and cardiovascular complications. Besides premature cell senescence, 2 main mechanisms are involved in FPLD: impaired adipocyte differentiation and lipid droplet, corresponding to two of the main causes of FPLD: LMNA-related FPLD2 and PLIN-related FPLD4. The objective of this study was to compare the clin...