ea0011p909 | Thyroid | ECE2006
Schomburg L
, Riese C
, Michaelis M
, Griebert E
, Klein MO
, Sapin R
, Schweizer U
, Koehrle J
Selenium (Se) is indispensable for enzymatic activities of glutathione peroxidases (GPx) involved in antioxidative defense and deiodinase isozymes (Dio) that control thyroid hormone (TH) action. Se deficiency can impact negatively on thyroid galnd funtioning and TH metabolism and thereby perturb development and metabolism. We have generated Se-deficient mice by genetic inactivation of Selenoprotein P (SePP), the main plasma Se carrier. SePP-KO mice display decreased serum and ...